HL-Logo-vertical-white

“Ubiquitin-Mediated Proteolysis and Cell Sensitivity to Camptothecin”

Hervé Jacquiau, J.D., Ph.D., M.Sc., D.E.A.
Date:
March 1, 2002

Hervé Jacquiau, Ph.D. co-authored this article discussing Camptothecin (CPT) stabilizes a covalent DNA topoisomerase I (Top1 p)-DNA complex that is converted into irreversible lesions in S-phase and induces cell death. To define cellular processes that recognize and repair CPT-induced lesions, a yeast genetic screen to isolate mutants with enhanced sensitivity to Top1p poisons at 35°C was developed.

Hervé Jacquiau, J.D., Ph.D., M.Sc., D.E.A.
Hervé Jacquiau, J.D., Ph.D., M.Sc., D.E.A. Of Counsel
Hahn Loeser
Powered by  GDPR Cookie Compliance
Privacy Overview

This website uses cookies so that we can provide you with the best user experience possible. Cookie information is stored in your browser and performs functions such as recognising you when you return to our website and helping our team to understand which sections of the website you find most interesting and useful.