Hervé Jacquiau, J.D., Ph.D., M.Sc., D.E.A.
Herve Jacquiau, Ph.D. co-authored this article on the diverse effects on SUMO conjugation, induced by defects in Ubc9 or a SUMO specific protease, alter the cytotoxic consequences of Top1 activity. DNA topoisomerase I (Top1) constitutes the cellular target of camptothecin (CPT), which stabilizes a covalent Top1-DNA intermediate. During S-phase the CPT-Top1-DNA complexes are converted into lethal lesions that induce cell cycle arrest and cell death. To define cellular processes that protect cells from CPT-induced lesions, conditional mutants with enhanced sensitivity to Top1 poisons were isolated in yeast genetic screens.
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