“Defects in SUMO Conjugation and DeSUMOylation Alter Cell Sensitivity to DNA Topoisomerase I-induced DNA Damage”

Hervé Jacquiau, J.D., Ph.D., M.Sc., D.E.A.

Hervé Jacquiau, Ph.D. is the co-author of this publication that appeared in the Journal of Biological Chemistry focusing on the important functions of Eukaryotic DNA topoisomerase I (Top1p) in DNA replication, transcription, and recombination. The results from provide insights into the complexities of SUMO conjugation and the confounding effects of SUMO modification on Top1p function and cell sensitivity to genotoxic agents.

Hervé Jacquiau, Ph.D., assists in all aspects of patent practice, including patent prosecution and litigation. His background covers a variety of technologies, particularly biotechnology, bioengineering, biochemistry, molecular biology and microbiology. Hervé received his Ph.D. degree from the University of Cambridge after investigating the genetic and biochemical features responsible for the biodegradation of toxic pollutants.

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