“BCR-ABL1 Alters SDF-1α–Mediated Adhesive Responses Through the β2 Integrin LFA-1 in Leukemia Cells”

Mona Malik, Ph.D., B.Sc.

Mona Malik is a co-author of this article published in The Blood Journal, which focuses on how BCR-ABL1  in  malignant  cells constitutively increases expression of activation-dependent  epitopes  of  the β2 integrin LFA-1. This is associated with the complete loss of responsiveness of LFA-1 to SDF-1–induced “inside-out” signaling involving CXCR4 and Lyn, leading to aberrant adhesive responses. This data provides a novel, LFA-1–mediated mechanism whereby BCR-ABL1 inhibits SDF-1 action in  malignant  progenitors.

Mona Malik, Ph.D., supports patent prosecution and litigation and provides technical and scientific guidance in various fields of life sciences, including cell biology, immunology/immunotherapy, genetics, biochemistry, pharmacology, virology, oncology, plant sciences and agriculture. With an advance degree and more than a dozen years of research experience, Mona brings noteworthy credentials to the patent issues of intellectual property. She earned a Ph.D. from the University of Cambridge after investigating complex mechanisms of chromosomal gene recombination and gene replacement.

To view the entire article, please visit www.bloodjournal.org.