"Alterations in the SUMO-Conjugating Enzyme UBC9 Distinguish Enzyme Functions Essential for Cell Viability and Responses to DNA Damage

Hervé Jacquiau, Ph.D. co-authored this article on how DNA topoisomerase I (Topl) catalyzes changes in DNA topology by reversibly cleaving a single strand in duplex DNA. Camptothecin (CPT) induces cell killing in S-phase by stabilizing a covalent intermediate formed between Top l and the 3 phosphoryl end of DNA. Yet, the cellular processes involved in the recognition and repair of CPT-induced DNA lesions remain poorly understood.

Hervé Jacquiau, Ph.D., assists in all aspects of patent practice, including patent prosecution and litigation. His background covers a variety of technologies, particularly biotechnology, bioengineering, biochemistry, molecular biology and microbiology. Hervé received his Ph.D. degree from the University of Cambridge after investigating the genetic and biochemical features responsible for the biodegradation of toxic pollutants.